Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Anti-VDAC1/Porin Rabbit mAb - Mitochondrial Loading Control
Catalog number :AT0019
- Overview
- Description
- anti-VDAC1 Rabbit monoclonal antibody - Mitochondrial Marker
- Reactivity
- Mouse, Rat, Human
- Tested applications
- WB: 1:1000-1:5000. Predicted molecular weight: 31 kDa.
- Product Picture
- Properties
- Immunogen
Synthetic peptide surrounding amino acid 189 of human VDAC
- Clonality
- Rabbit Monoclonal, clone number: 10D6
- Isotype
- Rabbit IgG
- Form
- Liquid
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 30% Glycerol, 0.5% BSA, PBS
- Storage instruction
- Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Applications
- WB Image
Western blot - VDAC/Porin antibody (AT0019)
Predicted band size : 31 kDa
Related Products
| Catalog number | AT0020 |
| Catalog number | AT1579 |
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