Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis. Expressed in many adult tissues. Abundant in heart and skeletal muscle. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 OPR domain. Contains 1 protein kinase domain. Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
Anti-MEK5 Rabbit mAb
Catalog number :AT0340
- Overview
- Description
- Rabbit monoclonal antibody to MEK5
- Reactivity
- Mouse, Rat, Chicken, Human
- Tested applications
- WB: Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).
IP: Use a concentration of 2 - 5 µg/ml.
ELISA: Use a concentration of 0.01 - 0.1 µg/ml.
- Properties
- Clonality
- Monoclonal, clone number: 5E7
- Isotype
- Rabbit IgG
- Form
- Liquid
Preservative: None
Constituents: Tris buffered saline, pH 7.2 with antibody stabilizer
- Storage instruction
- Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Host
- Rabbit
- Applications
- WB Image
All lanes : Anti-MEK5 antibody at 1/1000 dilution
Lane 1 : Whole cell lysates derived from mouse liver
Lane 2 : Negative control
Predicted band size : 49 kDa
Observed band size : 49 kDa
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